Alpha Yap: Cadherins hold it all together

Alpha Yap: Cadherins hold it all together

H omotypic adhesion between surface receptors called cadherins is essential to the integrity of epithelial sheets. But cadherins aren't just passive anchors that allow cells to stick together. Instead, by coupling to the actin cytoskeleton, they can generate tension to affect the structure and resiliency of individual cells and tissues. How are contractile forces generated at cadherin junctions...

Putting it all together.

With an extensive career in cancer care, Catherine Gillespie is able to pull nursing and policy together.

Putting it all together.

• Let's look at some relatively simple privileged programs • How do they combine the different mechanisms we've seen? • What are the threats? The defenses?

Pulling It All Together

Hundreds of pathways, thousands of cell types, tens of thousands of molecules, megabytes of data, and seemingly infinite biological networks—the study of life has perhaps never been more daunting. What ever happened to the explanation from Miller-Urey’s experiment on life’s origins, involving just four compounds, or the simple (okay, merely seemingly simple) unidirectional flow from DNA/RNA/pro...

Tying It All Together